Clinic companion · Selim Medical Press

Biologic Joint Preservation

The Clinical Guide to PRP in Osteoarthritis — consultation, product record, review, safety and teaching cases

Educational aid for licensed healthcare professionals. Not medical advice. Not a medical device. No recommendation is produced. PRP is not approved for osteoarthritis.

Consultation worksheet

Start with the decision in front of you. Work through the sections, then build a consultation note that another clinician could follow. Deferring PRP, addressing another diagnosis and arranging referral are legitimate outcomes. Nothing here is scored.

ScopeThe pathway centers on knee OA. Evidence from the knee does not establish the same benefit in another joint; see Chapter 14 before transferring assumptions.

QG3Patient and clinical problem

QG3Safety review

QG3Expected benefit and limitations

No suitability scoreAge, BMI and synovitis do not form a validated PRP suitability score. No probability of success is assigned.

QG4Put PRP beside the alternatives

Compare options against the same patient goal. Several may be used together. Tick each option you discussed.

OptionDecision it helps addressDiscuss or document
Keep the comparison fairAvoid selecting treatment from an isolated rank or pooled effect size. Trials differ in patients, products, comparators and follow-up. Listing options does not imply equal evidence or universal endorsement.

QG5Shared decision and teach back

Use the patient's goal to anchor the conversation. Check understanding before asking for consent.

“We are considering whether this treatment might improve your pain and function. We cannot promise that it will rebuild cartilage or prevent a future joint replacement.”
“PRP preparations and study results vary. Improvement is possible, but some people obtain no useful benefit. We should compare the options that fit your situation.”

Teach back — the patient explained, in their own words:

Patient's choice

QG6Medication and procedure plan

Resolve uncertainty before collection. A medicine list and a signed consent form do not by themselves establish readiness.

IssueRecordDecision rule
What remains uncertainLaboratory effects on platelet function do not establish the clinical benefit of a fixed medication washout. This worksheet prescribes no universal NSAID or steroid interval. Patient safety and the medicine's indication take priority.

QG3Decision

Handover to rehabilitation (QG11, optional)

Basis: practice framework; QG3–QG6 and QG11; Chapters 7–13 and 15; sources Q1, Q2 and Q6. Use locally approved consent materials.

Characterize what was administered

An interpretable outcome requires a traceable product and procedure. Use measured values where available. Mark unmeasured characteristics unknown; do not substitute a kit's marketing claim.

QG7Dose arithmetic

not measured
not measured
Absolute platelet dose
—
billion platelets delivered
Fold enrichment
—
PRP count ÷ baseline count
Platelet recovery (yield)
—
share of drawn platelets kept in the prepared PRP
Course total so far
—
billion platelets, this injection plus earlier ones
How the dose is calculatedFor a count in ×10⁹/L: dose in billions = count × injected volume in mL ÷ 1,000. Illustration: 800 ×10⁹/L × 5 mL ÷ 1,000 = 4 billion platelets. Use the volume actually injected, not the volume prepared; syringe and needle dead space retain part of the product. This describes exposure; it does not establish an optimal dose. Fold enrichment alone does not describe the absolute dose or establish equivalence between preparations.
How recovery is calculatedRecovery % = (PRP volume prepared × PRP count) ÷ (blood volume × baseline count) × 100. Illustration: (6 mL × 800) ÷ (30 mL × 250) × 100 = 64%. Pair each volume with a count measured in the same state: if the baseline count comes from a separate tube without the kit's anticoagulant, enter the blood volume drawn excluding anticoagulant. If the PRP count exceeds the analyzer's validated range, dilute as the analyzer's instructions direct and correct for the dilution. Recovery describes how the device and operator performed; it is not a clinical outcome or a target.

PlanExpected yield before preparation

An estimate for planning the draw, made before any product exists. It depends entirely on the recovery rate you enter, so use your own device's measured recovery. After preparation, record the measured counts above; this estimate does not replace them.

Expected platelets in the PRP
—
billion platelets
Expected PRP concentration
—
×10⁹/L (= ×10³/µL)
Expected concentration factor
—
× baseline
Expected dose, planned injection
—
billion platelets
How the estimate is calculatedExpected platelets (billion) = baseline count (×10⁹/L) × blood volume (mL) ÷ 1,000 × recovery. Expected concentration = expected platelets × 1,000 ÷ PRP volume. Expected concentration factor = recovery × blood volume ÷ PRP volume. Illustration with a 60% recovery: 250 × 54 ÷ 1,000 × 0.60 = 8.1 billion; 8.1 × 1,000 ÷ 7 = 1,157 ×10⁹/L; 0.60 × 54 ÷ 7 = 4.6×. The illustration's recovery is an example, not a typical or recommended value.

A3Product and procedure record

Basis: product documentation framework; QG7 and A3; Chapters 3, 4, 11 and 12; source Q5. Arithmetic only; no dose or recovery target. Recovery and course-total calculations and the expected-yield estimate added 1 October 2026. Numerical preparation settings must come from the applicable validated process and manufacturer instructions.

Track outcomes that change the plan

Choose a validated measure appropriate to the joint. Record its version, scoring direction and assessment conditions, and use the same measure over time. Declare the meaningful-change criterion and its source before the result is known.

QG8Measure and criterion

No universal thresholdUse a threshold appropriate to the instrument and population. A single percentage or point change does not apply to every scale. This page does not reproduce or license a proprietary questionnaire.
MeasureBaselineReview 1Review 2

QG9What pattern do you and the patient see?

Classify together. Select the row that fits; the right-hand box shows the next step from the reassessment pathway.

Separate the outcomesPain and function may improve without demonstrated structural repair. Record structural assessment separately, with its clinical reason.

Basis: author-designed reassessment pathway and practice framework; QG8–QG9 and S4; Chapters 6, 7, 9, 10 and 13; source Q3. Repeat-treatment timing and selection remain uncertain.

Safety and aftercare triage

Severe or progressive symptoms require assessment whenever they occur. Neither early onset nor absence of fever excludes infection. Tick what the patient reports; the highest level of response is shown.

Clinician assessmentEvaluate suspected infection promptly through the local acute-joint pathway. Arrange appropriate examination and sampling when indicated. Timing alone does not establish a benign PRP flare. This screen does not diagnose a complication.

QG10Give the patient a route to help

These details are also copied into patient page B2. Explain where to go if the clinic cannot be reached.

Basis: source Q4 for suspected septic arthritis; Chapters 12–13 for PRP aftercare; QG10, S4 and B2.

Branching teaching cases

Eight composite teaching examples from Appendix E. Choose a first decision, read the reasoning, then work through the new information and the branches. Your answers are not saved.

Preferred first decisions: 0 of 0 attempted

High-level summary tables

For rapid orientation before a consultation or clinical huddle. A concern in the right-hand column does not label the patient as unsuitable; it identifies the next question, support or assessment needed.

Evidence labels

Labels identify the basis of advice. They are editorial labels, not a new grading system. Apply them to individual claims.

LabelMeaning
Keep the distinctions visibleThe 2026 AAPM&R statement contains five evidence-based recommendations and eleven consensus best practices. Cite the relevant statement before converting advice into a mandatory step. Its public summary supports consideration of PRP for selected mild-to-moderate knee OA with persistent symptoms after conservative care; it does not promise benefit.

Sources for the clinic tools

    Tools reviewed on 16 September 2026. The book's chapters retain their own numbered bibliographies.

    Patient pages

    Personalize each page, confirm understanding, then print it. Use your applicable consent process. Contact details entered on the Safety triage tab are copied into B2.

    B1 · Patient information to discuss with your healthcare professional

    PRP: making your treatment choice

    What is PRP?

    Platelet-rich plasma is prepared from a sample of your blood and injected into the treatment area. Preparations differ. Your clinician should explain the product and procedure being proposed.

    What might it do?

    Some patients report less pain or better function, but useful benefit is not guaranteed. PRP has not been established as a way to rebuild your joint cartilage, cure osteoarthritis or prevent a future joint replacement.

    What are the alternatives?

    Depending on your situation, options may include education, tailored exercise, weight-management support, medicines, another injection or specialist assessment. Ask how each option fits the activity you want to improve.

    What should I understand before deciding?

    Ask about pain or swelling after treatment, bruising, bleeding, infection and other risks relevant to you. Discuss your medicines, planned rehabilitation, follow-up and who to contact if symptoms concern you.

    Your decision record

    Check your understanding

    Can you explain what PRP might help, what it cannot promise, and which alternatives you could choose? You may ask for more time before deciding.

    B2 · Keep this page with your individual aftercare plan

    After PRP: your plan and when to get help

    Medicines

    Follow the written plan from your treating team. Do not stop prescribed aspirin, blood thinners or other medicines on your own. Ask the team if the instructions are unclear or your pain relief is inadequate.

    Activity

    Follow the activity and rehabilitation plan agreed for you. Ask when and how to increase activity. A fixed calendar cannot account for every patient's symptoms and function.

    Get urgent assessment at any time

    Seek urgent help for severe or increasing pain, a hot swollen joint, inability to bear weight, fever or shaking chills, spreading redness or discharge. These symptoms need assessment even on the first day. No fever does not mean there is no infection. Do not wait until a routine follow-up appointment.

    For collapse, breathing difficulty or other emergency symptoms, contact local emergency services. If you cannot reach your clinic about urgent joint symptoms, use the urgent-care route below.

    If the treatment does not help

    Tell the team at review, or sooner if symptoms worsen. The next step should include reassessment and discussion of alternatives. Another injection is not an automatic next step.

    Your contacts and review

    About this companion

    This is the free clinic companion to Biologic Joint Preservation: The Clinical Guide to PRP in Osteoarthritis — Science, Evidence, Controversy, and Patient-Centered Practice by Dr. Hafez Selim, MD, PhD, Dr. Abir Hegazy, MB BCh, MSc (PM&R), and Gana Sharafeldin, MB BCh BAO (Selim Medical Press). It turns the book's Clinic Quick Guide (QG1–QG12), High-Level Summary Tables (S1–S4), procedure forms (Appendix A), patient pages (Appendix B) and branching cases (Appendix E) into working screens.

    ScreenBook source
    ConsultationQG3 selection worksheet, QG4 alternatives, QG5 shared decision, QG6 medication and procedure plan, QG11 consultation note and handover
    Product & doseQG7 minimum record and dose arithmetic; A3 product and procedure record
    Review & next stepQG8 outcome tracking; QG9 nonresponse and repeat-treatment pathway; S4
    Safety triageQG10 safety and aftercare triage; A4 and B2 safety wording
    Teaching casesAppendix E, cases E1–E8
    At a glanceS1–S4; QG12 evidence labels and sources Q1–Q6
    Patient pagesAppendix B, pages B1–B2

    It runs entirely in your browser. There are no analytics, no tracking, no cookies and no network requests. Nothing you type is stored or transmitted, and reloading the page discards everything. Do not enter identifiable patient information.

    The companion to the authors' earlier textbook, Platelet-Rich Plasma for Degenerative Osteoarthritis, remains available at abdu94-hash.github.io/prp-oa-tool, with a candidacy screener and an evidence explorer.

    Tools reviewed: 16 September 2026. Guideline positions, regulatory provisions, coverage determinations and device instructions change. Re-verify before relying on anything here.

    Terms of use (15 clauses)